Carl Elliott writes in his book, White Coat, Black Hat: Adventures on the dark Side of Medicine, that, in our patchwork style regulatory system, no one is keeping track about how many injuries and deaths befall healthy subjects in clinical trials. Nobody is monitoring the effect that so many trials have on the health of serial guinea pigs, and nobody is even entirely certain whether trials generate reliable data. And, unfortunately, according to a recent John Hopkins study, the vast majority of already published and relevant clinical trials of a given drug, device or procedure, are routinely ignored by scientists conducting new research on the same topic..

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